The pathology department at Heartlands Hospital is part of University Hospitals Birmingham and serves Heartlands, Good Hope and Solihull Hospitals and in addition to providing services for GPs in and around Birmingham and Solihull
The current UKAS accredited Glandular Fever screen offered by HEFT laboratories has been discontinued by Alpha Laboratories (the supplier). We are currently in the process of validating a replacement Glandular Fever screening kit (also supplied by Alpha Laboratories). An extension to scope will be submitted for this assay to be accredited at our next UKAS assessment in October 2018.
Due to difficulties in obtaining sufficient kit supplies for our Renin workload, it is with regret that we will no longer be able to offer the measurement of Renin, and subsequently Aldosterone , from this laboratory.
We have been working closely with our colleagues at University Hospital Birmingham (UHB) and will be sending work there from the 28/2/2018. The Renin assay provided by UHB is an Immunoassay method (IDS iSYS) for renin mass with reference ranges comparable to the ones used at Heartlands. See attached information. The aldosterone method is a comparable assay by LC/MSMS.
The UHB laboratory is a UKAS accredited laboratory. The aldosterone assay is already UKAS accredited and the Renin immunoassay will be assessed by UKAS as part of their next extension to scope application.
The aldosterone assay is in essence identical to the one used at Heartlands. It is a mass spec method and should have the same characteristics. The http://www.heftpathology.com/item/aldosterone.html information should be applicable.
There will be a slight change in the ratio cut offs used to take into account the renin method. We will be using the Endocrine guidelines ranges and use the 91 cut off with and Aldosterone greater than 750 as a “screen” positive interpretation. This is taken from the Endocrine guidelines on the investigation of Conns. https://academic.oup.com/jcem/article/93/9/3266/2596343
From a sample processing point of view continue to send the samples to Heartlands and we will transport the samples to UHB.
Please contact the lab or duty biochemist if you have any queries
In light of the recent merger between Heart of England Foundation Trust and University Hospitals Birmingham, and in order to consolidate the tests we provide as a trust, CA19-9 samples will now be analysed at the Queen Elizabeth Hospital pathology laboratory.
There is no change to specimen handling instructions or reference ranges. Serum separator tubes (SST) is the recommended sample type.
For further information please do not hesitate to contact us: Duty Biochemist: Telephone: 01214242193 or Bleep: 2506
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The Trust Laboratories at Heartlands Hospital, Good Hope Hospital and Solihull Hospital were awarded UKAS (United Kingdom Accreditation Service) accreditation to the internationally recognised ISO 15189 standard in May 2015. For a list of accredited tests and other information please visit the test database http://www.heftpathology.com/frontpage/test-database.html.
Tests not appearing on this scope are either under consideration or in the process of accreditation and so currently remain outside of our scope of accreditation. However, these tests have been validated to the same high standard as accredited tests and are performed by the same trained and competent staff.
For further information contact Louise Fallon, Quality Manager, 0121 424 1235