Preferred Sample Type
Suitable Specimen Types
- Serum
- EDTA Plasma
- Li Hep Plasma
Specimen Transport
First class postSample Processing in Laboratory
Place sample in toxicology rack.Sample Preparation
None requiredTurnaround Time
3 days.Sample Stability
Keep refrigerated. 4 degrees.Clobazam
General Information
Clobazam is a 1,5 benzodiazepine derivative utilized as a sedative, anticonvulsant and anti-anxeity agent in a number of European countries since 1978. Daily adult doses for adults may range from 20 – 60 mg.
Clobzam in overdosage causes moderate sedation with up to 300 mg has been ingested without serious toxic effects. However, genetic metabolic deficiences in the metabolism of clobazam may lead to accumulation of desmethylclobazam leading to symptoms such as severe ataxia and somnolence.
Patient Preparation
For TDM, sample should be taken prior to dose. If toxicity is suspected, take sample at earliest opportunity
Notes
Clobazam measured by HPLC-DAD. Serum from gel tubes (yellow top) will NOT be analysed.
Reference Range
Therapeutic use of clobazam is associated with concentrations of up to 0.4 mg/L. (TIAFT reference blood level list of therapeutic and toxic substances, September 2004).
Specifications
- EQA Scheme?: Yes
- EQA Status: LGC QUARTZ, LGC CLIN TOX