Preferred Sample Type
Suitable Specimen Types
- Serum
- EDTA Plasma
- Li Hep Plasma
Specimen Transport
First class postSample Processing in Laboratory
Place sample in toxicology rack.Sample Preparation
None requiredTurnaround Time
3 days.Sample Stability
Keep refrigerated. 4 degrees.Cyclizine
General Information
Cyclizine is an antihistaminic drug with antiemetic and sedative effects that has been in use since 1954 for the prevention or treatment of motion sickness. The usual adult oral dose for motion sickness is 50 mg taken 30 minutes before travel and repeated 4-6 hours as needed, not to exceed 200 mg daily. A 50 mg i.m or i.v dose is frequently used for the treatment of post-operative vomiting or acute cardiac chest pain, and it may be repeated every 8 hours.
The adverse effects seen with cyclizine therapy include dry mouth, headache, blurred vision, drowsiness, tachycardia, urinary retention and restlessness. Cyclizine overdosage can cause central nervous system depression or stimulation, euphoria, hypertension, convulsions, coma and death from respiratory paralysis.
Patient Preparation
For TDM, sample should be taken prior to dose. If toxicity is suspected, take sample at earliest opportunity
Notes
Cyclizine measured by HPLC-DAD.
Please note this assay is not currently UKAS accredited
Reference Range
Therapeutic use of cyclizine typically associated with concentrations of up to 0.25 mg/L. Toxicity is generally associated with concentrations > 0.75 mg/L. (Schulz et al. Critical Care 2012, 16:R136)
Specifications
- EQA Scheme?: Yes
- EQA Status: LGC QUARTZ, LGC CLIN TOX