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Department

Toxicology

Preferred Sample Type

Dihydrocodeine

Suitable Specimen Types

  • Serum
  • EDTA Plasma
  • Li Hep Plasma
A minimum of 500 ul of plasma/serum is required.

Specimen Transport

First class post

Sample Processing in Laboratory

Place sample in toxicology rack.

Sample Preparation

None required

Turnaround Time

3 days.

Sample Stability

Keep refrigerated. 4 degrees.

Dihydrocodeine

General Information

Dihydrocodeine is a semisynthetic narcotic analgesic,  prepared by the hydrodgenation of codeine. It is supplied, sometimes in combination with acetaminophen, as the bitartrate salt in 7.5 - 30 mg normal release tablets or capsules and 60 - 120 mg extended-release tablets for oral administration. Single doses of 7.5 - 30 mg of the normal-release forms may be taken every 4-6 hours, with a maximum daily limit of 192 mg.

Adverse reactions to dihydrocodeine include dizziness, drowsiness, lightheadedness, nausea and constipation. Overdosage may result in respiratory depression, coma, convulsions, cardiovascular collapse and death. 

Please note, this assay is for the quantitative determination of dihydrocodeine in blood. Dihydrocodeine use may also be detected via our urinary Drugs of Abuse Screen by LC-MS/MS.

Patient Preparation

No patient preperation required.

Notes

Dihydrocodeine analysed by LC-MS/MS

Reference Range

Please contact the laboratory for guidance in therapy.

 

Units - ug/L

Specifications

  • EQA Scheme?: Yes
  • EQA Status: LGC QUARTZ, LGC CLIN TOX