Preferred Sample Type

Amiodarone

Suitable Specimen Types

  • Serum
1 mL of serum

Specimen Transport

First Class Post

Sample Processing in Laboratory

No special transport requirements

Sample Preparation

Centrifuge upon receipt and separate serum.

Turnaround Time

1 week

Sample Stability

4ºC

Amiodarone

General Information

Amiodarone is an antiarrhythmic agent. Usually measured to confirm compliance. Amiodarone has a very long half-life (extending to several weeks) and only needs to be given once daily (but high doses may cause nausea unless divided). Many weeks or months may be required to achieve steady-state serum amiodarone concentration. Amiodarone contains iodine and can cause disorders of thyroid function; both hypothyroidism and hyperthyroidism may occur. Clinical assessment alone is unreliable, and laboratory tests should be performed before treatment and every 6 months. Thyroxine (T4) may be raised in the absence of hyperthyroidism; therefore tri-iodothyronine (T3), T4, and thyroid-stimulating hormone (thyrotrophin, TSH) should all be measured. A raised T3 and T4 with a very low or undetectable TSH concentration suggests the development of thyrotoxicosis. The thyrotoxicosis may be very refractory, and amiodarone should usually be withdrawn at least temporarily to help achieve control; treatment with carbimazole may be required. Hypothyroidism can be treated with replacement therapy without withdrawing amiodarone if it is essential; careful supervision is required.

Patient Preparation

Test not available. To discuss further contact duty biochemist (2506)

Notes

Test not available. To discuss further contact duty biochemist (2506)

Reference Range

Test not available. To discuss further contact duty biochemist (2506)

Specifications

  • EQA Scheme?: Yes
  • EQA Status:

    NULL

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The Trust Laboratories at Heartlands Hospital, Good Hope Hospital and Solihull Hospital were awarded UKAS (United Kingdom Accreditation Service) accreditation to the internationally recognised ISO 15189 standard in May 2015. For a list of accredited tests and other information please visit the test database http://www.heftpathology.com/frontpage/test-database.html.
Tests not appearing on this scope are either under consideration or in the process of accreditation and so currently remain outside of our scope of accreditation. However, these tests have been validated to the same high standard as accredited tests and are performed by the same trained and competent staff.

For further information contact Louise Fallon, Quality Manager, 0121 424 1235

UKAS HEFT