Preferred Sample Type

Apolipoprotein A and B

Suitable Specimen Types

  • EDTA Plasma
  • Li Hep Plasma
1 mL blood

Specimen Transport

First class post

Sample Processing in Laboratory


Sample Preparation

Centrifuge sample and separate plasma

Turnaround Time

1 week

Sample Stability


Apolipoprotein A and B

General Information

Apolipoprotein A (ApoA)is the major protein component of high density lipoprotein (HDL). Due to the difficulty in measuring HDL, ApoA may represent a more reliable indicator of HDL status. Measurement is also indicated for diagnosis of ApoA deficiencies such as Tangier disease and fish eye disease.

Apolipoprotein B (ApoB)is the primary apolipoprotein of low-density lipoprotein (LDL). Due to the difficulty of directly measuring LDL, some feel that measurement of ApoB could be a more reliable indicator of cardiovascular disease risk than the measurement of LDL cholesterol.

Measurement is also indicated in the diagnosis of disorders of the synthesis and secretion of the ApoB containing lipoproteins which include but are not limited to: familial combined hyperlipidaemia, hyperapobetalipoproteinaemia and hypobetalipoproteinaemia.

Both ApoA and ApoB may provide additional information in specific situations but do not replace the lipid tests commonly available.

Patient Preparation



Lithium Heparin plasma may be used for Apolipoprotein A.

Serum (red topped tube i.e. no gel) may be used for Apo A and B.

Reference Range

Apo A:1.0-2.2g/L

Apo B:0.6-1.3g/L


  • EQA Scheme?: Yes
  • EQA Status:

    No scheme available

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Protection of Personal Information – Laboratory Medicine comply with the Trust Data Protection Policy and have procedures in place to allow the Directorate and it’s employees to comply with the Data Protection Act 1998 and associated best practice and guidance.

The Trust Laboratories at Heartlands Hospital, Good Hope Hospital and Solihull Hospital were awarded UKAS (United Kingdom Accreditation Service) accreditation to the internationally recognised ISO 15189 standard in May 2015. For a list of accredited tests and other information please visit the test database
Tests not appearing on this scope are either under consideration or in the process of accreditation and so currently remain outside of our scope of accreditation. However, these tests have been validated to the same high standard as accredited tests and are performed by the same trained and competent staff.

For further information contact Louise Fallon, Quality Manager, 0121 424 1235