Preferred Sample Type


Suitable Specimen Types

  • Serum
  • EDTA Plasma
  • Li Hep Plasma
A minimum of 500 ┬Ál of plasma/serum is required.

Specimen Transport

First class post

Sample Processing in Laboratory

Place sample in toxicology rack.

Sample Preparation

None required

Turnaround Time

3 days.

Sample Stability

Keep refrigerated. 4 degrees.


General Information

Bisoprolol is a synthetic beta-adrenergic blocking agent that has been used clinically since 1984 for the treatment of hypertension. It is available as the hemifumurate salt in 2.5 - 10 mg tablets for oral administration, occasionally in combination with hydrochlorothiazide. The usual adult dose is 5 - 10 mg daily.

Side effects during bisoprolol therapy include nausea, vomiting, diarrhoea, weakness and fatigue. Several patients survived acute overdosage with up to 2000 mg of the drug after experiencing bradycardia and/or hypotension. 

Patient Preparation

For TDM, sample should be taken prior to dose. If toxicity is suspected, take sample at earliest opportunity


Bisoprolol measured by HPLC-DAD.

Please note this assay is not currently UKAS accredited

Reference Range

Therapeutic range: 0.01 - 0.1 mg/L. (Schulz et al. Critical Care 2012, 16:R136).


  • EQA Scheme?: Yes

The laboratories at Heartlands Hospital, Good Hope Hospital and Solihull Hospital form part of the services provided by University Hospitals Birmingham and are UKAS (United Kingdom Accreditation Service) accredited to the ISO 15189:2012 standard. For a list of accredited tests and other information please visit the UKAS website using the following link:

  • Heartlands, Good Hope and Solihull Hospital pathology laboratories are a UKAS accredited medical laboratory No.8217
  • United Kingdom Health Security Agency laboratory is a UKAS accredited medical laboratory No.8213

Tests not appearing on the UKAS Schedule of Accreditation currently remain outside of our scope of accreditation. However, these tests have been validated to the same high standard as accredited tests and are performed by the same trained and competent staff.

For further test information, please visit the test database:

Protection of personal information - Laboratory Medicine comply with the Trust Data Protection policy and have procedures in place to allow the Directorate and its employees to comply with the Data Protection act  1998 and associated best practice and guidance.

For further information contact Louise Fallon, Quality Manager, 0121 424 1235