Referred Work

Preferred Sample Type


Suitable Specimen Types

  • Serum
2ml serum

Specimen Transport

2mL Serum (Gel 5mL Yellow tube). Transport fresh or freeze within <2hrs.


Sample Processing in Laboratory

Sent Frozen to referral laboratory

Sample Preparation

Freeze within 2 hours of venepuncture

Turnaround Time

Up to 20 days from receipt at Referral Laboratory

Sample Stability


General Information

C1q is the initiating molecule for the classical activation pathway of complement. Deficiencies or defects in the molecule lead to a reduced or absent CH50 value. Familial deficiency is rare but reduced levels may be associated with SLE, recurrent bacterial infections and with glomerulonephritis. C1q levels are usually only measured in cases where CH50 is absent or the patient has increased susceptability to infection. The exception to this is in the identification of the consumptive defect in acquired angioedema, where levels are almost always low

Reference Range

Supplied by reference laboratory

50-250 mg/L

Source of Reference Range

Collaborative study between reference laboratory and PRU


  • EQA Scheme?: No
  • EQA Status:

    No EQA scheme available

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HTA licence number is 12366

Protection of Personal Information – Laboratory Medicine comply with the Trust Data Protection Policy and have procedures in place to allow the Directorate and it’s employees to comply with the Data Protection Act 1998 and associated best practice and guidance.

The Trust Laboratories at Heartlands Hospital, Good Hope Hospital and Solihull Hospital were awarded UKAS (United Kingdom Accreditation Service) accreditation to the internationally recognised ISO 15189 standard in May 2015. For a list of accredited tests and other information please visit the test database
Tests not appearing on this scope are either under consideration or in the process of accreditation and so currently remain outside of our scope of accreditation. However, these tests have been validated to the same high standard as accredited tests and are performed by the same trained and competent staff.

For further information contact Louise Fallon, Quality Manager, 0121 424 1235