First Class Post to ref. lab.
C3 nephritic factor is an IgG antibody which stabilises the alternative pathway C3 convertase leading to continuous C3 breakdown. If positive in patient with renal disease it strongly sugests mesangio-capillary nephritis. Approx two thirds of patients with partial lipodystrophy have a low C3 and circulating C3 nephritic factor, and have an increased tendency to develop mesangio-capillary nephritis. Clinical utility - MPGN Type II, familial lipodystrophy, transiently in post-streptococal glomerulonephritis.
This test is only indicated if the C3 concentration is low
No EQA scheme available
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The Trust Laboratories at Heartlands Hospital, Good Hope Hospital and Solihull Hospital were awarded UKAS (United Kingdom Accreditation Service) accreditation to the internationally recognised ISO 15189 standard in May 2015. For a list of accredited tests and other information please visit the test database http://www.heftpathology.com/frontpage/test-database.html.
Tests not appearing on this scope are either under consideration or in the process of accreditation and so currently remain outside of our scope of accreditation. However, these tests have been validated to the same high standard as accredited tests and are performed by the same trained and competent staff.
For further information contact Louise Fallon, Quality Manager, 0121 424 1235