Referred Work

Preferred Sample Type

C3 Nephritic factor

Suitable Specimen Types

  • Serum
2mL serum

Sample Processing in Laboratory

First Class Post to ref. lab.

Sample Preparation


Turnaround Time

2-4 weeks

Sample Stability


C3 Nephritic factor

General Information

C3 nephritic factor is an IgG antibody which stabilises the alternative pathway C3 convertase leading to continuous C3 breakdown. If positive in patient with renal disease it strongly sugests mesangio-capillary nephritis. Approx two thirds of patients with partial lipodystrophy have a low C3 and circulating C3 nephritic factor, and have an increased tendency to develop mesangio-capillary nephritis. Clinical utility - MPGN Type II, familial lipodystrophy, transiently in post-streptococal glomerulonephritis.

Patient Preparation



This test is only indicated if the C3 concentration is low

Reference Range



  • EQA Scheme?: No
  • EQA Status:

    No EQA scheme available

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Protection of Personal Information – Laboratory Medicine comply with the Trust Data Protection Policy and have procedures in place to allow the Directorate and it’s employees to comply with the Data Protection Act 1998 and associated best practice and guidance.

The Trust Laboratories at Heartlands Hospital, Good Hope Hospital and Solihull Hospital were awarded UKAS (United Kingdom Accreditation Service) accreditation to the internationally recognised ISO 15189 standard in May 2015. For a list of accredited tests and other information please visit the test database
Tests not appearing on this scope are either under consideration or in the process of accreditation and so currently remain outside of our scope of accreditation. However, these tests have been validated to the same high standard as accredited tests and are performed by the same trained and competent staff.

For further information contact Louise Fallon, Quality Manager, 0121 424 1235