Preferred Sample Type


Suitable Specimen Types

  • Serum
  • EDTA Plasma
  • Li Hep Plasma
A minimum of 500 µl of plasma/serum is required.

Specimen Transport

First class post

Sample Processing in Laboratory

Place sample in toxicology rack.

Sample Preparation

None required

Turnaround Time

3 days.

Sample Stability

Keep refrigerated. 4 degrees.


General Information

Chlorpheniramine is a sedating antihistamine that has been used clincally since 1951. It is administered orally in single doses of 0.5 – 4 mg and by i.m injection in doses of 5 mg. It is nearly always found in combination with decongestants, antitussives, expectorants and and analgesics. Most of these oral formulations are taken 3 – 6 times daily,

Adverse effects associated with chlorpheniramine therapy include sedation, headache, dry mouth and urinary retention. Chlorpheniramine produces symptoms of central nervous system depression in overdosage.


Chlorpheniramine measured by HPLC-DAD. 

Reference Range

Toxic concentrations of chlorpheniramine are extremely subject dependant. Please contact the laboratory for interpretation.


  • EQA Scheme?: Yes

The laboratories at Heartlands Hospital, Good Hope Hospital and Solihull Hospital form part of the services provided by University Hospitals Birmingham and are UKAS (United Kingdom Accreditation Service) accredited to the ISO 15189:2012 standard. For a list of accredited tests and other information please visit the UKAS website using the following link:

  • Heartlands, Good Hope and Solihull Hospital pathology laboratories are a UKAS accredited medical laboratory No.8217
  • United Kingdom Health Security Agency laboratory is a UKAS accredited medical laboratory No.8213

Tests not appearing on the UKAS Schedule of Accreditation currently remain outside of our scope of accreditation. However, these tests have been validated to the same high standard as accredited tests and are performed by the same trained and competent staff.

For further test information, please visit the test database:

Protection of personal information - Laboratory Medicine comply with the Trust Data Protection policy and have procedures in place to allow the Directorate and its employees to comply with the Data Protection act  1998 and associated best practice and guidance.

For further information contact Louise Fallon, Quality Manager, 0121 424 1235