Preferred Sample Type

Dehydroepiandrosterone Sulphate (DHAS) (DHEAS)

Suitable Specimen Types

  • Serum
1 ml whole blood

Specimen Transport

Usual transport to laboratory.

Sample Processing in Laboratory

Centrifuge and separate serum. Send serum to referral laboratory daily (Mon-Fri) by usual transport.

Sample Preparation

Centrifuge and separate serum

Turnaround Time

1 week

Sample Stability

Store separated serum samples at 4ºC

Dehydroepiandrosterone Sulphate (DHAS) (DHEAS)

General Information

Measurement of dehydroepiandrosterone sulphate (DHEA-SO4, DHAS), an adrenal steroid, is important to investigations of abnormal hair growth (hirsutism) and balding (alopecia) in women. It is also of value in the assessment of adrenarche and delayed puberty. The DHAS in circulation originates almost entirely from the adrenals, though in men some may also derive from the testes, partly accounting for the sex difference which emerges at about age 15. This hormone is not produced by the ovaries even under pathological conditions. In itself DHAS is only weakly androgenic, but it can metabolize to more potent androgens like androstenedione and testosterone, and thus be an indirect cause of hirsutism or virilisation. Unlike cortisol, DHAS does not exhibit significant diurnal variation. Unlike testosterone, it does not circulate bound to sex-hormone binding globulin and hence is not influenced by alterations in the level of this carrier protein. Its abundance, together with its within-day and day-to-day stability, makes it an excellent direct indicator of adrenal androgen output. High DHAS levels are often encountered in the polycystic ovary syndrome, showing that adrenal hyperandrogenism is a fairly typical facet of this syndrome.

Patient Preparation

None

Reference Range

For specimens analysed before 13/05/14, reference ranges:

Male: 2.2 – 15.2 umol/l Female: 1.0 – 11.7 umol/l Age dependant. Individual results should be interpreted with caution since DHAS increases at puberty, peaks in the 3rd decade then declines.

 

For specimens received by the laboratory after 13/05/14, refer to the table below for age/gender-specific reference ranges (supplied by referral laboratory):

 

DHAS

µmol/L

Children

 

< 1 week

2.93-16.5

1-4 weeks

0.86-11.7

1-12 months

0.09-3.35

1-4 y

0.01-0.53

5-9 y

0.08-2.31

years

Females

Males

10-14

0.92-7.60

0.66-6.70

15-19

1.77-9.99

1.91-13.40

20-24

4.02-11.00

5.73-13.40

25-34

2.68-9.23

4.34-12.20

35-44

1.65-9.15

2.41-11.60

45-54

0.96-6.95

1.20-8.98

55-64

0.51-5.56

1.40-8.01

65-74

0.26-6.68

0.91-6.76

≥ 75

0.33-4.18

0.44-3.34

Specifications

  • EQA Scheme?: Yes
  • EQA Status: NEQAS

Copyright heftpathology 2013, 2014, 2015, 2016, 2017, 2018

HTA licence number is 12366

Protection of Personal Information – Laboratory Medicine comply with the Trust Data Protection Policy and have procedures in place to allow the Directorate and it’s employees to comply with the Data Protection Act 1998 and associated best practice and guidance.

The Trust Laboratories at Heartlands Hospital, Good Hope Hospital and Solihull Hospital were awarded UKAS (United Kingdom Accreditation Service) accreditation to the internationally recognised ISO 15189 standard in May 2015. For a list of accredited tests and other information please visit the test database http://www.heftpathology.com/frontpage/test-database.html.
Tests not appearing on this scope are either under consideration or in the process of accreditation and so currently remain outside of our scope of accreditation. However, these tests have been validated to the same high standard as accredited tests and are performed by the same trained and competent staff.

For further information contact Louise Fallon, Quality Manager, 0121 424 1235

UKAS HEFT