Department

Biochemistry

Preferred Sample Type

Gamma Glutamyl Transferase (GGT)

Suitable Specimen Types

  • Serum
  • EDTA Plasma
  • Li Hep Plasma
5-10 mL vacutainer (minimum sample volume 20 uL)

Sample Processing in Laboratory

Usual

Sample Preparation

Centrifuge

Turnaround Time

1 day

Sample Stability

Usual. Samples are stable for 7 days when stored at 4˚C or for up to 1 year if stored at -20˚C

Gamma Glutamyl Transferase (GGT)

General Information

Gamma-glutamyl transferase (GGT) is an enzyme which is found in hepatocytes and biliary epithelial cells. Measurement of its activity provides a sensitive indicator of hepatobiliary disease although it is of no value in distinguishing between cholestatic or hepatocellular disease. In biliary obstruction, serum GGT activity may increase before that of ALP. Raised GGT levels have been reported in a variety of clinical conditions including:

  • pancreatic disease
  • myocardial infarction
  • chronic obstructive pulmonary disease
  • renal failure
  • diabetes
  • alcoholism

Drugs such as phenytoin and barbiturates may cause high GGT levels due to enzyme induction.

The reported sensitivity of a raised GGT for detecting alcohol ingestion has ranged from 52% to 94%.

Patient Preparation

None

Notes

Haemolysis interferes with this assay. No significant interference from high bilirubin or lipaemia.

Anticonvulsants, barbiturates, alcohol can increase GGT activity.

Reference Range

12-64 IU/L (Males)
9-36 IU/L (Females)

Source : Abbott Diagnostics

Specifications

  • EQA Scheme?: Yes
  • EQA Status:

    NEQAS and WEQAS

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Protection of Personal Information – Laboratory Medicine comply with the Trust Data Protection Policy and have procedures in place to allow the Directorate and it’s employees to comply with the Data Protection Act 1998 and associated best practice and guidance.

The Trust Laboratories at Heartlands Hospital, Good Hope Hospital and Solihull Hospital were awarded UKAS (United Kingdom Accreditation Service) accreditation to the internationally recognised ISO 15189 standard in May 2015. For a list of accredited tests and other information please visit the test database http://www.heftpathology.com/frontpage/test-database.html.
Tests not appearing on this scope are either under consideration or in the process of accreditation and so currently remain outside of our scope of accreditation. However, these tests have been validated to the same high standard as accredited tests and are performed by the same trained and competent staff.

For further information contact Louise Fallon, Quality Manager, 0121 424 1235

UKAS HEFT