PAROX

Preferred Sample Type

Paroxetine

Suitable Specimen Types

  • Serum
  • EDTA Plasma
  • Li Hep Plasma
500 ul of serum/plasma

Specimen Transport

Usual

Sample Processing in Laboratory

Centrifuge and place in toxicology box in cold room.

Sample Preparation

Centrifuge

Turnaround Time

3 working days

Sample Stability

4 ºC

Paroxetine

General Information

Paroxetine (Paxil, Pexeva, Seroxat) is a serotonin reuptake inhibitor, belonging to a class of drugs which contains fluoxetine and sertraline and has been used since 1978 as an antidepressive agent. 

Adverse reactions for paroxetine include somnolence, agitation, tremor, insomnia, nausea and muscular weakness. Concurrent administration of a monoamine oxidase inhibitor may cause extreme agitation, muscle rigidity, hyperthermia, hypertension, delerium and coma (the serotonin syndrome). Hepatotoxicity may occur with therapeutic usage and severe neuroleptic malignant syndome has been described. Vertigo, nausea and comiting have been reported in patients following discontinuation of paroxetine therapy.

Patient Preparation

For TDM, sample should be taken prior to dose. If toxicity is suspected, take sample at earliest opportunity

Notes

Please avoid use of gel seperator tubes.

Reference Range

Toxicity associated with paroxetine levels > 0.35 mg/L.

Please contact the laboratory if paroxetine measurement is required for therapeutic monitoring purposes.

Paroxetine is measured by LC-MS/MS, as part of our Selective Serotonin Re-uptake Inhibitor (SSRI)  anti-depressant combined method.

Specifications

  • EQA Scheme?: Yes
  • EQA Status: LGC QUARTZ, LGC CLIN TOX

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Tests not appearing on this scope are either under consideration or in the process of accreditation and so currently remain outside of our scope of accreditation. However, these tests have been validated to the same high standard as accredited tests and are performed by the same trained and competent staff.

For further information contact Louise Fallon, Quality Manager, 0121 424 1235

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