Preferred Sample Type

Protein S

Specimen Transport

Standard transport to laboratory

Sample Processing in Laboratory

Sample should be centrifuged

Sample Preparation

To arrive in laboratory within 4 hours of collection. Samples for any coagulation tests must be filled to within a tolerance of 10% of the fill line indicated on the sample tube. Any sample filled above or below this level will be reported as overfilled o

Turnaround Time

10 days

Sample Stability

8 hours

Protein S

Patient Preparation

Tests requested on these patients must conform with BCSH guidelines:

  • Venous thrombosis under age 45
  • Recurrent venous thrombosis
  • Family history
  • Venous thrombosis in unusual site e.g. mesenteric vein
  • Spontaneous neonatal thrombosis
  • Skin necrosis on coumarins
  • Arterial thrombosis under age 30 e.g. CVA


Patient should not be on any anticoagulant treatment for a minimum of six weeks prior to testing

Samples should not be taken during or immediately after an acute event. Please allow a minimum of six weeks prior to testing

Protein S levels may be reduced in pregnancy, by oral contraceptives or hormone replacement therapy. 

Reference Range

Male     74-146%

Female 55-124%


  • EQA Scheme?: Yes
  • EQA Status: NEQAS

The laboratories at Heartlands Hospital, Good Hope Hospital and Solihull Hospital form part of the services provided by University Hospitals Birmingham and are UKAS (United Kingdom Accreditation Service) accredited to the ISO 15189:2012 standard. For a list of accredited tests and other information please visit the UKAS website using the following link:

  • Heartlands, Good Hope and Solihull Hospital pathology laboratories are a UKAS accredited medical laboratory No.8217
  • United Kingdom Health Security Agency laboratory is a UKAS accredited medical laboratory No.8213

Tests not appearing on the UKAS Schedule of Accreditation currently remain outside of our scope of accreditation. However, these tests have been validated to the same high standard as accredited tests and are performed by the same trained and competent staff.

For further test information, please visit the test database:

For further information contact Louise Fallon, Quality Manager, 0121 424 1235